Results: In the tail suspension and forced swimming tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice. Methods: The antidepressant effects of (+)- MK-801 (0.1mg/kg) and (-)- MK-801 (0.1mg/kg) in the social defeat stress model were examined. This study was conducted to examine the effects of (+)- MK-801 and its less potent stereoisomer, (-)- MK-801, in the social defeat stress model of depression.
Yang, Bangkun Ren, Qian Ma, Min Chen, Qian-Xueīackground: Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)- MK-801, is inconsistent. Antidepressant Effects of (+)- MK-801 and (-)- MK-801 in the Social Defeat Stress Model
